{"id":1232,"date":"2015-07-13T16:56:37","date_gmt":"2015-07-13T07:56:37","guid":{"rendered":"http:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=1232"},"modified":"2015-07-13T17:58:04","modified_gmt":"2015-07-13T08:58:04","slug":"%e9%87%8d%e5%90%88%e5%8c%96%e3%81%99%e3%82%8b%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%ab%e4%bd%9c%e7%94%a8%e3%81%99%e3%82%8b%e5%8c%96%e5%90%88%e7%89%a9%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/1232.html","title":{"rendered":"\u91cd\u5408\u5316\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u4f5c\u7528\u3059\u308b\u5316\u5408\u7269\u306e\u65b0\u305f\u306a\u8a55\u4fa1\u65b9\u6cd5\u306e\u958b\u767a\u306b\u6210\u529f 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id=\"attachment_1237\" style=\"width: 310px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/9c296e9806acd64b0f263c75e0e40de9.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1237\" class=\"size-medium wp-image-1237\" alt=\"\u56f31\" src=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/9c296e9806acd64b0f263c75e0e40de9-300x78.jpg\" width=\"300\" height=\"78\" srcset=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/9c296e9806acd64b0f263c75e0e40de9-300x78.jpg 300w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/9c296e9806acd64b0f263c75e0e40de9.jpg 961w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-1237\" class=\"wp-caption-text\">\u56f31\uff1aFtsZ\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cd\u5408\u4f53\u5316(A)\u3068\u7d30\u80de\u5206\u88c2(B)<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u3057\u305f\u304c\u3063\u3066\uff0c\u3053\u306eFtsZ\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4e8c\u91cf\u4f53\uff0c\u591a\u91cf\u4f53\u306b\u306a\u308b\u3053\u3068\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308c\u3070\uff0c\u7d30\u83cc\u306f\u5206\u88c2\u3067\u304d\u306a\u304f\u306a\u308a\uff0c\u5897\u6b96\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059\u3002\u3064\u307e\u308a\uff0cFtsZ\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e8c\u91cf\u4f53\u5316\u3092\u963b\u5bb3\u3059\u308b\u5316\u5408\u7269\u306f\u65b0\u3057\u3044\u6297\u83cc\u85ac\u306e\u300c\u7a2e\u300d\u306b\u306a\u308a\u5f97\u307e\u3059\u3002<\/p>\n<p><b>\uff08\u7814\u7a76\u624b\u6cd5\uff09<\/b><\/p>\n<p>\u672c\u7814\u7a76\u3067\u306f\u65b0\u3057\u3044\u6297\u83cc\u85ac\u306e\u300c\u7a2e\u300d\u306b\u306a\u308b\u5316\u5408\u7269\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306b\uff0cmodeFRONTIER<sup>TM<\/sup>\u3068AutoDock\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308b\u30d0\u30fc\u30c1\u30e3\u30eb\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u86cd\u5149\u76f8\u4e92\u76f8\u95a2\u5206\u5149\u6cd5\uff08Fluorescence cross-correlation spectroscopy, 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id=\"attachment_1238\" style=\"width: 310px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/df64f8c293148abaef92ad7ec8606091.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1238\" class=\"size-medium wp-image-1238\" alt=\"\u56f32\" src=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/df64f8c293148abaef92ad7ec8606091-300x106.jpg\" width=\"300\" height=\"106\" srcset=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/df64f8c293148abaef92ad7ec8606091-300x106.jpg 300w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/df64f8c293148abaef92ad7ec8606091.jpg 679w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-1238\" class=\"wp-caption-text\">\u56f32\uff1a2\u6b21FCCS\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u7d50\u679c\u3002\u6a2a\u8ef8\u306f\u5316\u5408\u7269\u756a\u53f7\uff08888\u7a2e\u985e\uff09\uff0c\u7e26\u8ef8\u306fFtsZ\u306e\u4e8c\u91cf\u4f53\u5316\u306e\u6307\u6a19\u3092\u793a\u3059\u3002\u3064\u307e\u308a\uff0c\u3053\u306e\u56f3\u3067\u306f888\u672c\u306e\u68d2\u30b0\u30e9\u30d5\u304c\u4e26\u3093\u3067\u3044\u308b\uff08\u9ed2\u304f\u5857\u308a\u3064\u3076\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\uff09\u3002\u68d2\u30b0\u30e9\u30d5\u304c\u4f4e\u3051\u308c\u3070\u4f4e\u3044\u307b\u3069FtsZ\u306e\u4e8c\u91cf\u4f53\u5316\u963b\u5bb3\u52b9\u679c\u304c\u9ad8\u3044\u5316\u5408\u7269\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u3002\u6700\u3082\u963b\u5bb3\u52b9\u679c\u304c\u9ad8\u304b\u3063\u305f\u5316\u5408\u7269\u306f\u767d\u77e2\u5370\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/p><\/div>\n<p>71\u7a2e\u985e\u306e\u5316\u5408\u7269\u306e\u3046\u3061\uff0c\u4e8c\u91cf\u4f53\u5316\u963b\u5bb3\u52b9\u679c\u304c\u9ad8\u304b\u3063\u305f6\u7a2e\u985e\u306e\u5316\u5408\u7269\u306b\u3064\u3044\u3066\uff0c\u8868\u9762\u30d7\u30e9\u30ba\u30e2\u30f3\u5171\u9cf4\u6cd5\uff08Surface plasmon resonance\uff1aSPR\uff09<sup>\u6ce8\uff17<\/sup>\u3092\u7528\u3044\u3066\uff0c\u5316\u5408\u7269\u3068FtsZ\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u306e\u7279\u7570\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u307e\u305f\uff0c\u3053\u306e6\u7a2e\u985e\u306b\u3064\u3044\u3066\uff0c\u6297\u83cc\u4f5c\u7528\u3092\u78ba\u304b\u3081\u305f\u3068\u3053\u308d\uff0c\u30e1\u30c1\u30b7\u30ea\u30f3\u8010\u6027\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\uff08MRSA\uff0c\u4e00\u822c\u7684\u306b\u591a\u5264\u8010\u6027\u3092\u793a\u3059\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\uff09\u3092\u542b\u3080\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306b\u5bfe\u3057\uff0c\u6297\u83cc\u4f5c\u7528\u3092\u6301\u3064\u5316\u5408\u7269\u304c\u6700\u7d42\u7684\u306b1\u7a2e\u985e\u898b\u3064\u304b\u308a\u307e\u3057\u305f\u3002<b><\/b><\/p>\n<p><b>\u00a0\uff08\u4eca\u5f8c\u3078\u306e\u671f\u5f85\uff09<\/b><\/p>\n<p>\u9ec4\u8272\u30d6\u30c9\u30a6\u7403\u83cc\u306f\u7a2e\u3005\u306e\u6297\u83cc\u85ac\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u7372\u5f97\u3057\u3084\u3059\u3044\u6027\u8cea\u304c\u3042\u308a\uff0c\u591a\u5264\u8010\u6027\u83cc\uff08MRSA\uff09\u3068\u3057\u3066\u9662\u5185\u611f\u67d3\u62e1\u5927\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u898b\u3064\u304b\u3063\u305f\u5316\u5408\u7269\u306f\u3042\u304f\u307e\u3067\u65b0\u3057\u3044\u6297\u83cc\u85ac\u306e\u300c\u7a2e\u300d\u3067\u3042\u308a\uff0c\u5b9f\u969b\u306e\u85ac\u3068\u3057\u3066\u7528\u3044\u308b\u306b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u958b\u767a\u304c\u5fc5\u8981\u3067\u3059\u304c\uff0c\u591a\u5264\u8010\u6027\u83cc\u306b\u5bfe\u3057\u3066\u53cd\u6483\u306e\u7cf8\u53e3\u3068\u306a\u308b\u5316\u5408\u7269\u3067\u3042\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\uff0c\u79c1\u305f\u3061\u304c\u958b\u767a\u3057\u305f\u65b9\u6cd5\u306f\u3053\u308c\u307e\u3067\u5b9a\u91cf\u7684\u306a\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u96e3\u3057\u304b\u3063\u305f\u300c\u591a\u91cf\u4f53\u3092\u5f62\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u300d\u306b\u5bfe\u3057\u3066\u5fdc\u7528\u53ef\u80fd\u3067\u3059\u3002\u3059\u306a\u308f\u3061\uff0c\u795e\u7d4c\u7d30\u80de\u5185\u3067\u767a\u751f\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u51dd\u96c6\u4f53\uff08\u591a\u91cf\u4f53\uff09\u304c\u539f\u56e0\u3067\u751f\u3058\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\uff0c\u305f\u3068\u3048\u3070\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u306e\u6cbb\u7642\u85ac\u306e\u767a\u898b\u306b\u3082\u5f79\u7acb\u3063\u3066\u3044\u304f\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u7814\u7a76\u8ad6\u6587\u540d\uff1aScreening for FtsZ dimerization inhibitors using fluorescence cross-correlation spectroscopy and surface resonance plasmon analysis\uff08FtsZ\u30bf\u30f3\u30d1\u30af\u8cea\u4e8c\u91cf\u4f53\u5316\u306e\u963b\u5bb3\u5316\u5408\u7269\u3092\u767a\u898b\u3059\u308b\u305f\u3081\u306e\u86cd\u5149\u76f8\u4e92\u76f8\u95a2\u5206\u5149\u6cd5\u3068\u8868\u9762\u30d7\u30e9\u30ba\u30e2\u30f3\u5171\u9cf4\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6cd5\u306e\u958b\u767a\uff09<\/p>\n<p>\u8457\u8005\uff1a\u4e09\u570b\u65b0\u592a\u90ce<sup>1<\/sup>\uff0c\u5150\u7389\u8015\u592a<sup>2<\/sup>\uff0c\u4f50\u3005\u6728\u7ae0<sup>3<\/sup>\uff0c\u5dfb\u3000\u79c0\u6a39<sup>4<\/sup>\uff0c\u5c0f\u5e73\u5c1a\u8f1d<sup>4<\/sup>\uff0c\u68df\u671d\u96c5\u6674<sup>5<\/sup>\uff0c\u524d\u4ef2\u52dd\u5b9f<sup>6<\/sup>\uff0c\u91d1\u57ce\u653f\u5b5d<sup>1<\/sup><\/p>\n<p><sup>1<\/sup>\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u5148\u7aef\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\uff0c<sup>2<\/sup>\u5317\u6d77\u9053\u5927\u5b66\u5275\u6210\u7814\u7a76\u6a5f\u69cb\uff0c<sup>3<\/sup>\u7523\u696d\u6280\u8853\u7dcf\u5408\u7814\u7a76\u6240\u30d0\u30a4\u30aa\u30e1\u30c7\u30a3\u30ab\u30eb\u7814\u7a76\u90e8\u9580\uff0c<sup>4<\/sup>\u5869\u91ce\u7fa9\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e\u30b3\u30a2\u75be\u60a3\u5275\u85ac\u7814\u7a76\u6240\uff0c<sup>5<\/sup>\u5317\u6d77\u9053\u5927\u5b66\u60c5\u5831\u57fa\u76e4\u30bb\u30f3\u30bf\u30fc\uff0c<sup>6<\/sup>\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662<\/p>\n<p>\u516c\u8868\u96d1\u8a8c\uff1aPLOS ONE<\/p>\n<p>\u516c\u8868\u65e5\uff1a\u65e5\u672c\u6642\u9593\uff08\u73fe\u5730\u6642\u9593\uff092015\u5e747\u67089\u65e5\uff08\u6728\uff09\u5348\u524d3\u6642\uff08\u7c73\u56fd\u6771\u90e8\u6642\u9593\u30002015\u5e747\u67088\u65e5\uff08\u6c34\uff09\u5348\u5f8c2\u6642\uff09<\/p>\n<div class=\"btbox\">\n<table width=\"100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td class=\"txt-m\" width=\"54%\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/td>\n<td align=\"right\" width=\"46%\"><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2015\/07\/67de2f1ce750e9bd8bbc07c7a521072a.pdf\"><img loading=\"lazy\" decoding=\"async\" title=\"\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\" alt=\"\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\" src=\"https:\/\/www.lfsci.hokudai.ac.jp\/images\/bt\/dl-pdf.jpg\" width=\"250\" height=\"60\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\uff08\u80cc\u666f\uff09 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[&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-1232","post","type-post","status-publish","format-standard","hentry","category-sci"],"_links":{"self":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/1232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/comments?post=1232"}],"version-history":[{"count":6,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/1232\/revisions"}],"predecessor-version":[{"id":1247,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/1232\/revisions\/1247"}],"wp:attachment":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/media?parent=1232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/categories?post=1232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/tags?post=1232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}