{"id":3086,"date":"2019-05-27T12:22:33","date_gmt":"2019-05-27T03:22:33","guid":{"rendered":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=3086"},"modified":"2019-05-27T12:24:45","modified_gmt":"2019-05-27T03:24:45","slug":"l-%e4%b9%b3%e9%85%b8%e8%bc%b8%e9%80%81%e4%bd%93%e3%81%8c%e5%9f%ba%e8%b3%aa%e3%82%92%e9%81%b8%e6%8a%9e%e3%81%99%e3%82%8b%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0%e3%82%92%e8%a7%a3%e6%98%8e%ef%bd%9e","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/3086.html","title":{"rendered":"L-\u4e73\u9178\u8f38\u9001\u4f53\u304c\u57fa\u8cea\u3092\u9078\u629e\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\uff5e\u57fa\u8cea\u8f38\u9001\u7d4c\u8def\u306b\u5b58\u5728\u3059\u308b2\u3064\u306e\u6b8b\u57fa\u306e\u91cd\u8981\u306a\u5f79\u5272\uff5e"},"content":{"rendered":"<p><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2019\/05\/\u4e95\u95a2\u7814\u30b5\u30de\u30ea\u30fc\u56f3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-3087\" src=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2019\/05\/\u4e95\u95a2\u7814\u30b5\u30de\u30ea\u30fc\u56f3-300x125.jpg\" alt=\"\" width=\"300\" height=\"125\" srcset=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2019\/05\/\u4e95\u95a2\u7814\u30b5\u30de\u30ea\u30fc\u56f3-300x125.jpg 300w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2019\/05\/\u4e95\u95a2\u7814\u30b5\u30de\u30ea\u30fc\u56f3-768x319.jpg 768w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2019\/05\/\u4e95\u95a2\u7814\u30b5\u30de\u30ea\u30fc\u56f3.jpg 865w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" 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4\u306f\uff0c\u751f\u4f53\u5185\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u5316\u5408\u7269\u3067\u3042\u308bL-\u4e73\u9178\u306e\u8f38\u9001\u3092\u62c5\u3046\u8f38\u9001\u4f53\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u306b\uff0chMCT1\u306fL-\u4e73\u9178\u306b\u52a0\u30485-\u30aa\u30ad\u30bd\u30d7\u30ed\u30ea\u30f3\u3092\u8f38\u9001\u3059\u308b\u4e00\u65b9\u3067\uff0chMCT4\u306f5-\u30aa\u30ad\u30bd\u30d7\u30ed\u30ea\u30f3\u3092\u8f38\u9001\u3057\u306a\u3044\u3068\u3044\u3046\u77e5\u898b\u304c\u5f97\u3089\u308c\u3066\u304a\u308a\uff0chMCT1\u3068hMCT4\u306e\u9593\u306b\u306f\u305d\u306e\u57fa\u8cea\u9078\u629e\u6027\u306e\u9055\u3044\u3092\u6c7a\u5b9a\u3059\u308b\u4f55\u3089\u304b\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5b58\u5728\u304c\u4e88\u6e2c\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3053\u3067\uff0c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306fhMCT1, 4\u306e\u4e88\u6e2c3\u6b21\u5143\u69cb\u9020\u3068\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u5375\u6bcd\u7d30\u80de\u3092\u7528\u3044\u305fhMCT1, 4\u306e\u8f38\u9001\u6d3b\u6027\u8a55\u4fa1\u7cfb\u3092\u5229\u7528\u3057\uff0chMCT1\u9078\u629e\u7684\u306a5-\u30aa\u30ad\u30bd\u30d7\u30ed\u30ea\u30f3\u8f38\u9001\u306b\u91cd\u8981\u306a2\u3064\u306e\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\uff0869\u756a\u76ee\u306e\u30e1\u30c1\u30aa\u30cb\u30f3\u6b8b\u57fa\u53ca\u3073367\u756a\u76ee\u306e\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u6b8b\u57fa\uff09\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\uff0chMCT1, 4\u306e\u57fa\u8cea\u9078\u629e\u306b\u95a2\u308f\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u304c\u660e\u3089\u304b\u3068\u306a\u308a\uff0c\u305d\u306e\u69cb\u9020\u3068\u6a5f\u80fd\u3068\u306e\u95a2\u9023\u306b\u65b0\u305f\u306a\u77e5\u898b\u3092\u4e0e\u3048\u307e\u3057\u305f\u3002\u5c06\u6765\u7684\u306b\uff0cL-\u4e73\u9178\u8f38\u9001\u4f53\u304c\u533b\u85ac\u54c1\u306e\u65b0\u305f\u306a\u6a19\u7684\u5206\u5b50\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\uff0c\u672c\u7814\u7a76\u6210\u679c\u306f\uff0c2019\u5e745\u670817\u65e5\uff08\u91d1\uff09\u306bCellular and Molecular Life Sciences\u8a8c\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\uff0c\u672c\u7814\u7a76\u306f\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u79d1\u5b66\u7814\u7a76\u8cbb\u88dc\u52a9\u91d1\uff0817J00013\uff09\u306e\u52a9\u6210\u3092\u53d7\u3051\uff0c\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u8ad6\u6587\u60c5\u5831<br \/>\n\u8ad6\u6587\u540d Homology modeling and site-directed mutagenesis identify amino acid residues<br \/>\nunderlying the substrate selection mechanism of human monocarboxylate transporters 1<br \/>\n\uff08hMCT1\uff09and 4\uff08hMCT4\uff09\uff08\u30db\u30e2\u30ed\u30b8\u30fc\u30e2\u30c7\u30ea\u30f3\u30b0\u6cd5\u304a\u3088\u3073\u90e8\u4f4d\u7279\u7570\u7684\u5909\u7570\u5c0e\u5165\u6cd5\u3092\u5229\u7528<br \/>\n\u3057\u305f\u30d2\u30c8\u30e2\u30ce\u30ab\u30eb\u30dc\u30f3\u9178\u8f38\u9001\u4f53 hMCT1, 4 \u306e\u57fa\u8cea\u9078\u629e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u4e0e\u3059\u308b\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u306e<br \/>\n\u540c\u5b9a\uff09<br \/>\n\u8457\u8005\u540d \u4e8c\u6728\u60a0\u54c9 1,2\uff0c\u5c0f\u6797\u6b63\u7d00 3,4\uff0c\u9cf4\u6d77\u514b\u54c9 3\uff0c\u53e4\u5805\u5f69\u5b50 3\uff0c\u4e95\u95a2 \u5065 3,4\uff081\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d<br \/>\n\u79d1\u5b66\u9662, 2\u65e5\u672c\u5b66\u8853\u632f\u8208\u4f1a\u7279\u5225\u7814\u7a76\u54e1 DC, 3\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662, 4\u5317\u6d77\u9053\u5927\u5b66\u75c5<br \/>\n\u9662\u85ac\u5264\u90e8\uff09<br \/>\n\u96d1\u8a8c\u540d Cellular and Molecular Life Sciences\uff08\u751f\u7269\u5b66\uff0c\u751f\u7269\u533b\u5b66\u306e\u5c02\u9580\u8a8c\uff09<br \/>\n\uff24\uff2f\uff29 10.1007\/s00018-019-03151-z<br \/>\n\u516c\u8868\u65e5 2019 \u5e74 5 \u6708 17 \u65e5\uff08\u91d1\uff09\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\uff09<\/p>\n<div class=\"btbox\">\n<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td class=\"txt-m\" width=\"54%\">2019\/5\/27\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/td>\n<td align=\"right\" width=\"46%\"><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2019\/05\/20190527\u5317\u5927\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9_L-\u4e73\u9178\u8f38\u9001\u4f53\u304c\u57fa\u8cea\u3092\u9078\u629e\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\uff5e\u57fa\u8cea\u8f38\u9001\u7d4c\u8def\u306b\u5b58\u5728\u3059\u308b2\u3064\u306e\u6b8b\u57fa\u306e\u91cd\u8981\u306a\u5f79\u5272\uff5e.pdf\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.lfsci.hokudai.ac.jp\/images\/bt\/dl-pdf.jpg\" alt=\"\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\" width=\"250\" height=\"60\" 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