{"id":3192,"date":"2019-06-11T17:46:18","date_gmt":"2019-06-11T08:46:18","guid":{"rendered":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=3192"},"modified":"2019-06-11T17:46:35","modified_gmt":"2019-06-11T08:46:35","slug":"%e7%82%8e%e7%97%87%e6%80%a7%e7%9a%ae%e8%86%9a%e7%96%be%e6%82%a3%e3%81%ae%e7%97%85%e6%85%8b%e8%aa%bf%e7%af%80%e5%9b%a0%e5%ad%90%e3%81%8c%e7%99%ba%e7%8f%be%e3%81%99%e3%82%8b%e6%a9%9f%e6%a7%8b%e3%82%92","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/3192.html","title":{"rendered":"\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\u306e\u75c5\u614b\u8abf\u7bc0\u56e0\u5b50\u304c\u767a\u73fe\u3059\u308b\u6a5f\u69cb\u3092\u89e3\u660e\uff5e\u4e7e\u766c\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u96e3\u6cbb\u6027\u76ae\u819a\u708e\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u671f\u5f85\uff5e"},"content":{"rendered":"<p><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2019\/06\/\u5ba4\u672c\u5148\u751f\u56f3.jpg\"><img 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\/>\n\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u304b\u3089\uff0cTYK2 \u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3084\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3 17\u306e\u6301\u3064 mRNA \u5b89\u5b9a\u5316\u4f5c\u7528\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\uff0c\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3 17 \u304c\u5f15\u304d\u8d77\u3053\u3059\u708e\u75c7\u53cd\u5fdc\u3092\u6291\u5236\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\uff0c\u4e7e\u766c\u306e\u65b0\u305f\u306a\u6cbb\u7642\u85ac\u958b\u767a\u306e\u624b\u639b\u304b\u308a\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\uff0c\u672c\u7814\u7a76\u6210\u679c\u306f\uff0c2019 \u5e74 5 \u6708 16 \u65e5\uff08\u6728\uff09\u516c\u958b\u306e ImmunoHorizons \u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f<\/p>\n<p>\u8ad6\u6587\u60c5\u5831<br \/>\n\u8ad6\u6587\u540d I\u03baB-\u03b6 Expression Requires Both TYK2\/STAT3 Activity and IL-17\u2013Regulated mRNA Stabilization\uff08TYK2\/STAT3 \u30b7\u30b0\u30ca\u30eb\u3068 IL-17 \u4f9d\u5b58\u6027\u306e mRNA \u5b89\u5b9a\u5316\u304c I\u03baB-\u03b6\u767a\u73fe\u8abf\u7bc0\u3092\u62c5\u3046\uff09<br \/>\n\u8457\u8005\u540d \u5ba4\u672c\u7adc\u592a 1\uff0c\u591a\u548c\u4f73\u4f51 2\uff0c\u5927\u57a3\u5185\u512a\u4f9d 2 \uff0c\u4f50\u85e4\u4e9c\u7f8e 2\uff0c\u658e\u91ce\u7531\u4f73 3\uff0c\u5e73\u5cf6\u6d38\u57fa 2, \u7f8e\u6fc3\u53e3\u5e83\u5f25 2\uff0c\u935b\u4ee3\u60a0\u4e00 1\uff0c\u67cf\u5009\u6df3\u4e00 1\uff0c\u4e0b\u7530\u548c\u54c9 4\uff0c\u7e54\u8c37\u5065\u53f8 5\uff0c\u677e\u7530 \u6b63 1 \uff081\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76<br \/>\n\u9662\uff0c2 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u9662\uff0c3 \u5317\u6d77\u9053\u5927\u5b66\u85ac\u5b66\u90e8\uff0c4 \u5bae\u5d0e\u5927\u5b66\u533b\u5b66\u90e8\uff0c5 \u56fd\u969b\u533b\u7642\u798f\u7949\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\uff09<br \/>\n\u96d1\u8a8c\u540d ImmunoHorizons\uff08\u514d\u75ab\u5b66\u306e\u5c02\u9580\u8a8c\uff09<br \/>\n\uff24\uff2f\uff29 10.4049\/immunohorizons.1900023<br \/>\n\u516c\u8868\u65e5 2019 \u5e74 5 \u6708 16 \u65e5\uff08\u6728\uff09\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\uff09<\/p>\n<div class=\"btbox\">\n<table border=\"0\" width=\"100%\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td class=\"txt-m\" width=\"54%\">2019\/6\/11\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/td>\n<td align=\"right\" width=\"46%\"><a href=\"https:\/\/www.hokudai.ac.jp\/news\/190611_pr2.pdf\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.lfsci.hokudai.ac.jp\/images\/bt\/dl-pdf.jpg\" alt=\"\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\" width=\"250\" height=\"60\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u306e\u5ba4\u672c\u7adc\u592a\u8b1b\u5e2b\uff0c\u677e\u7530 \u6b63\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\uff0c\u708e\u75c7\u6027\u76ae\u819a\u75be\u60a3\u306e\u75c5\u614b\u5f62\u6210\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b I\u03baB-\u03b6\u304c\uff0c\u8868\u76ae\u89d2\u5316\u7d30\u80de\u5185\u3067\u767a\u73fe\u8a98\u5c0e\u3055\u308c\u308b\u5206\u5b50\u6a5f\u69cb\u306b\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3067\u3042\u308b TYK2\u304c\u5f79\u5272\u3092\u3082\u3064\u3053 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-3192","post","type-post","status-publish","format-standard","hentry","category-sci"],"_links":{"self":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/3192","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/comments?post=3192"}],"version-history":[{"count":3,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/3192\/revisions"}],"predecessor-version":[{"id":3196,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/3192\/revisions\/3196"}],"wp:attachment":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/media?parent=3192"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/categories?post=3192"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/tags?post=3192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}