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cell receptor\uff09\u3067\u75c5\u539f\u4f53\u306a\u3069\u7570\u7269\u3092\u8a8d\u8b58\u3057\u3001T\u7d30\u80de\u6d3b\u6027\u5316\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u305d\u3046\u3057\u305fT\u7d30\u80de\u6d3b\u6027\u5316\u306b\u3088\u308a\u75c5\u539f\u4f53\u6392\u9664\u304c\u4fc3\u9032\u3055\u308c\u3001\u611f\u67d3\u304c\u7d42\u606f\u3057\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001T\u7d30\u80de\u6d3b\u6027\u5316\u306e\u7570\u5e38\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u3084\u5897\u60aa\u5316\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001TCR\u3092\u4ecb\u3059\u308bT\u7d30\u80de\u5185\u4fe1\u53f7\u4f1d\u9054\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u514d\u75ab\u75be\u60a3\u5236\u5fa1\u306b\u304a\u3044\u3066\u3082\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p>\u7d30\u80de\u5185\u4fe1\u53f7\u4f1d\u9054\u306b\u304a\u3044\u3066\u3001\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3092\u59cb\u3081\u3068\u3059\u308b\u9175\u7d20\u7fa4\u3084\u8ee2\u5199\u56e0\u5b50\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b\u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50\u306e\u4e00\u3064\u3067\u3042\u308bSignal-transducing adaptor protein-2\uff08STAP-2\uff09\u306f\u3001TCR\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u76f4\u63a5\u7d50\u5408\u3057\u3066\u305d\u306e\u50cd\u304d\u3092\u5f37\u3081\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001STAP-2\u306e\u767a\u73fe\u91cf\u306b\u3088\u308a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u5897\u60aa\u5316\u304c\u5de6\u53f3\u3055\u308c\u305f\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001STAP-2\u306e\u767a\u73fe\u91cf\u3084\u50cd\u304d\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u65b0\u3057\u3044\u85ac\u306e\u958b\u767a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u30016\u670821\u65e5\uff08\u706b\uff09\u516c\u958b\u306eThe Journal of Immunology\u306eNext in the JI\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><strong>\u3010\u80cc\u666f\u3011<\/strong><\/p>\n<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u75c5\u539f\u4f53\u3068\u6226\u3046\u305f\u3081\u306b\u3001\u79c1\u305f\u3061\u306e\u8eab\u4f53\u306b\u306f\u514d\u75ab\u7cfb\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u8eab\u4f53\u306b\u4fb5\u5165\u3057\u305f\u7570\u7269\u3067\u3042\u308b\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306a\u3069\u3078\u306e\u5bfe\u6297\u7b56\u3092\u514d\u75ab\u5fdc\u7b54\u3068\u3044\u3044\u3001\u69d8\u3005\u306a\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u304c\u50cd\u304d\u307e\u3059\u3002\u6a39\u72b6\u7d30\u80de\u3084\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\u306f\u3001\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u3092\u8caa\u98df\u30fb\u5206\u89e3\u3057\u3001\u7570\u7269\u65ad\u7247\uff08\u6297\u539f\uff09\u3092\u63d0\u793a\u3057\u307e\u3059\u3002T\u7d30\u80de\u8868\u9762\u306b\u5b58\u5728\u3059\u308bT\u7d30\u80de\u53d7\u5bb9\u4f53\uff08TCR\uff09\u304c\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308b\u3068\u3001T\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001B\u7d30\u80de\u306e\u6297\u4f53\u7523\u751f\u3084\u611f\u67d3\u7d30\u80de\u306b\u5bfe\u3059\u308b\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u4e00\u9023\u306e\u514d\u75ab\u53cd\u5fdc\u306b\u3088\u308a\u3001\u7570\u7269\u304c\u6392\u9664\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>TCR\u306fCD3\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u7fa4\uff08\u03b3\u3001\u03b4\u3001\u03b5\u3001\u03b6\uff09\u306a\u3069\u7a2e\u3005\u306e\u86cb\u767d\u3068\u8907\u5408\u4f53\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u822c\u7684\u306b\u3001\u6297\u539f\u8a8d\u8b58\u306b\u3088\u308aTCR\u8907\u5408\u4f53\u306b\u5b58\u5728\u3059\u308b\u30ea\u30f3\u9178\u5316\u9175\u7d20LCK\u304cCD3\u03b6\u5206\u5b50\u5185\u306eITAM\u30e2\u30c1\u30fc\u30d5<sup>\uff0a2<\/sup>\u306e\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u306e\u30ea\u30f3\u9178\u5316\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u7d9a\u3044\u3066\u3001TCR\u4e0b\u6d41\u4fe1\u53f7\u5206\u5b50\u7fa4\u306e\u30c1\u30ed\u30b7\u30f3\u30ea\u30f3\u9178\u5316\u304c\u8d77\u3053\u308a\u3001NF-\u03baB\u3084NFAT\u7b49\u306eT\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u3067\u3042\u308bIL-2\u306a\u3069\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u8ee2\u5199\u56e0\u5b50\u304c\u6d3b\u6027\u5316\u3055\u308c\u307e\u3059\u3002\u7d50\u679c\u3001IL-2\u7523\u751f\u3084T\u7d30\u80de\u306e\u5897\u6b96\u30fb\u6d3b\u6027\u5316\u304c\u8d77\u3053\u308a\u3001\u7570\u7269\u306b\u5bfe\u3059\u308b\u514d\u75ab\u53cd\u5fdc\u304c\u5b8c\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u904e\u7a0b\u3067\u3001TCR\u3092\u4ecb\u3059\u308b\u4fe1\u53f7\u4f1d\u9054\u306f\u4e0d\u53ef\u6b20\u3067\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u4e00\u65b9\u3001\u7570\u5e38\u4ea2\u9032\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u767a\u75c7\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001TCR\u4fe1\u53f7\u4f1d\u9054\u306e\u5236\u5fa1\u6a5f\u69cb\u306e\u8a73\u7d30\u306a\u90e8\u5206\u306e\u5168\u4f53\u50cf\u306f\u672a\u3060\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3001\u305d\u306e\u89e3\u660e\u304c\u7a2e\u3005\u306e\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u6a5f\u5e8f\u306e\u89e3\u660e\u3084\u305d\u308c\u3089\u306e\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u5927\u304d\u304f\u8ca2\u732e\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u677e\u7530\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u7d30\u80de\u5185\u4fe1\u53f7\u4f1d\u9054\u306b\u304a\u3044\u3066\u3001\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3092\u59cb\u3081\u3068\u3059\u308b\u9175\u7d20\u7fa4\u3084\u8ee2\u5199\u56e0\u5b50\u306e\u6d3b\u6027\u5316\u3092\u5236\u5fa1\u3059\u308b\u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50\u306e\u4e00\u3064\u3067\u3042\u308bSTAP-2\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u50cd\u304d\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001STAP-2\u304c\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u767a\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u304a\u3044\u3066\u3069\u306e\u3088\u3046\u306b\u50cd\u304f\u304b\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u7814\u7a76\u624b\u6cd5\u3011<\/strong><\/p>\n<p>TCR\u4fe1\u53f7\u4f1d\u9054\u306b\u304a\u3051\u308bSTAP-2\u306e\u5f79\u5272\u3092\u89e3\u6790\u3059\u308b\u5b9f\u9a13\u6750\u6599\u3068\u3057\u3066\u3001\u91ce\u751f\u578b\u53ca\u3073STAP-2\u6b20\u640d\u30de\u30a6\u30b9\u304b\u3089\u56de\u53ce\u3057\u305fT\u7d30\u80de\u3084STAP\u22122\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u305f\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u682aJurkat\u7d30\u80de\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u63a1\u53d6\u3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\u30e2\u30c1\u30fc\u30d5\u3068LCK\u306e\u7d50\u5408\u3092\u5897\u5f37\u3055\u305b\u3001TCR\u4e0b\u6d41\u4fe1\u53f7\u4f1d\u9054\u3092\u5897\u5f37\u3055\u305b\u307e\u3057\u305f\u3002\u5373\u3061\u3001STAP-2\u306f\u6297\u539f\u523a\u6fc0\u306b\u3088\u3063\u3066LCK\u3068\u5f37\u304f\u7d50\u5408\u3057\u3001TCR\u4e0b\u6d41\u3078\u306e\u4fe1\u53f7\u4f1d\u9054\u3092\u5897\u5f37\u3055\u305b\u307e\u3059\u3002<\/p>\n<p>\u6b21\u306b\u3001STAP-2\u306e\u767a\u73fe\u610f\u7fa9\u306b\u3064\u3044\u3066\u3001\u7a2e\u3005\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u751f\u4f53\u5185\u8a55\u4fa1\u3092\u884c\u3044\u307e\u3057\u305f\u3002STAP-2\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3001\u30a2\u30af\u30cd\u83cc\u6ce8\u5c04\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\u8089\u82bd\u816b\u5f62\u6210\u53cd\u5fdc\u304c\u6e1b\u5f31\u3057\u3066\u304a\u308a\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<sup>\uff0a8<\/sup>IFN-\u03b3<sup>\uff0a9<\/sup>\u91cf\u3082\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001STAP-2\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3001MOG\u30da\u30d7\u30c1\u30c9\u514d\u75ab\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\u795e\u7d4c\u75c7\u72b6\u306a\u3069\u81e8\u5e8a\u75c7\u72b6\u304c\u8efd\u5fae\u3067\u3042\u308a\uff08\u56f32\uff09\u3001\u810a\u9ac4\u5185\u3078\u306eT\u7d30\u80de\u6d78\u6f64\u3084\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3IFN-\u03b3\u3001IL-17<sup>\uff0a10<\/sup>\u767a\u73fe\u306e\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306eEAE\u5b9f\u9a13\u7cfb\u3067\u306f\u3001EAE\u75c5\u72b6\u9032\u884c\u306b\u4f34\u3044\u810a\u9ac4\u5185\u3067STAP-2 mRNA\u767a\u73fe\u304c\u4ea2\u9032\u3059\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001MOG\u30da\u30d7\u30c1\u30c9\u7279\u7570\u7684TCR\u3092\u767a\u73fe\u3059\u308b2D2\u30de\u30a6\u30b9<sup>\uff0a11<\/sup>\u3068\u30ea\u30f3\u30d1\u7cfb\u7d30\u80de\u306bSTAP-2\u3092\u904e\u5270\u767a\u73fe\u3059\u308bSTAP-2\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\uff08Tg\uff09\u30de\u30a6\u30b9<sup>\uff0a12<\/sup>\u3092\u4ea4\u914d\u3057\u30012D2\/STAP-2 Tg\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002\u307b\u307c\u534a\u6570\u306e2D2\/STAP-2 Tg\u30de\u30a6\u30b9\u304cEAE\u3092\u81ea\u7136\u767a\u75c7\u3057\u3001\u307b\u3068\u3093\u3069\u306e\u30de\u30a6\u30b9\u304c\u6b7b\u306b\u307e\u3057\u305f\uff08\u56f32\uff09\u3002<\/p>\n<p>EAE\u8a98\u5c0e\u3057\u305f\u91ce\u751f\u578b\u53ca\u3073STAP-2\u6b20\u640d\u30de\u30a6\u30b9\u304b\u3089\u5358\u96e2\u3057\u305fCD4\u967d\u6027T\u7d30\u80de\u3092\u514d\u75ab\u4e0d\u5168\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3059\u308b\u5b9f\u9a13\u7cfb\u3082\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u91ce\u751f\u578bCD4\u967d\u6027T\u7d30\u80de\u79fb\u690d\u3067\u306fEAE\u304c\u767a\u75c7\u3057\u307e\u3059\u304c\u3001\u3001STAP-2\u6b20\u640d\u30de\u30a6\u30b9CD4\u967d\u6027T\u7d30\u80de\u79fb\u690d\u3067\u306fEAE\u304c\u767a\u75c7\u3057\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001STAP-2\u304c\u8db3\u5834\u3068\u306a\u3063\u3066\u5f62\u6210\u3055\u308c\u308bLCK\/STAP-2\/CD3\u03b6\u306e\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u304cTCR\u4fe1\u53f7\u4f1d\u9054\u3092\u6b63\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u3001\u3055\u3089\u306b\u3001\u305d\u306e\u904e\u5270\u306aT\u7d30\u80de\u6d3b\u6027\u5316\u304c\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u5897\u60aa\u5316\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u4eca\u5f8c\u3078\u306e\u671f\u5f85\u3011<\/strong><\/p>\n<p>\u514d\u75ab\u5fdc\u7b54\u3067\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306bSTAP-2\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u65b0\u3057\u304f\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001T\u7d30\u80de\u306b\u4f9d\u5b58\u3057\u305f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u5897\u60aa\u5316\u306b\u306fSTAP-2\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u6cbb\u7642\u85ac\u304c\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001STAP-2\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u8ad6\u6587\u60c5\u5831<\/strong><br \/>\n\u8ad6\u6587\u540d\u3000STAP-2 is a novel positive regulator of TCR-proximal signals\uff08STAP-2\u306fTCR\u4fe1\u53f7\u4f1d\u9054\u3092\u6b63\u306b\u5236\u5fa1\u3059\u308b\u65b0\u898f\u5206\u5b50\u3067\u3042\u308b\uff09<\/p>\n<p>\u8457\u8005\u540d\u3000\u9f4b\u85e4\u6d69\u5927<sup>\uff11<\/sup>\u3001\u67cf\u5009\u6df3\u4e00<sup>\uff11<\/sup>\u3001\u7bed\u6a4b\u5e83\u592a<sup>\uff11<\/sup>\u3001\u4f50\u3005\u6728\u60a0\u6597<sup>\uff11<\/sup>\u3001\u6cb3\u539f\u751f\u77e5<sup>\uff11<\/sup>\u3001\u95a2\u6839\u52c7\u4e00<sup>\uff12<\/sup>\u3001\u935b\u4ee3\u60a0\u4e00<sup>\uff11<\/sup>\u3001\u5ba4\u672c\u7adc\u592a<sup>\uff11<\/sup>\u3001\u4e00\u4e95\u502b\u5b50<sup>3<\/sup>\u3001\u4e2d\u53f8\u5bdb\u5b50<sup>4<\/sup>\u3001\u5409\u6751\u662d\u5f66<sup>4<\/sup>\u3001\u7e54\u8c37\u5065\u53f8<sup>5<\/sup>\u3001\u677e\u7530\u3000\u6b63<sup>\uff11<\/sup>\uff08<sup>1<\/sup>\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u3001<sup>2<\/sup>\u4eac\u90fd\u85ac\u79d1\u5927\u5b66\u3001<sup> 3<\/sup>\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u3001<sup> 4<\/sup>\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u533b\u5b66\u90e8\u3001<sup>5<\/sup>\u56fd\u969b\u533b\u7642\u798f\u7949\u5927\u5b66\u533b\u5b66\u90e8\uff09<\/p>\n<p>\u96d1\u8a8c\u540d\u3000Journal of Immunology\uff08\u514d\u75ab\u5b66\u306e\u56fd\u969b\u7684\u5c02\u9580\u8a8c\uff09<\/p>\n<p>\uff24\uff2f\uff29\u3000<a href=\"https:\/\/www.jimmunol.org\/content\/early\/2022\/06\/19\/jimmunol.2101014\">10.4049\/jimmunol.2101014<\/a><\/p>\n<p>\u516c\u8868\u65e5\u30002022\u5e746\u670821\u65e5\uff08\u706b\uff09\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\uff09<\/p>\n<p><strong>\u304a\u554f\u3044\u5408\u308f\u305b\u5148<\/strong><\/p>\n<p>\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u3000\u6559\u6388\u3000\u677e\u7530\u3000\u6b63\uff08\u307e\u3064\u3060\u3000\u305f\u3060\u3057\uff09<\/p>\n<p>\uff34\uff25\uff2c\u3000011-706-3243\u3000 \uff26\uff21\uff38\u3000011-706-4990\u3000 \u30e1\u30fc\u30eb\u3000tmatsuda@pharm.hokudai.ac.jp<\/p>\n<p>\uff35\uff32\uff2c\u3000<a href=\"https:\/\/www.pharm.hokudai.ac.jp\/eisei\/\">http:\/\/www.pharm.hokudai.ac.jp\/eisei\/index.html<\/a><\/p>\n<p><strong>\u914d\u4fe1\u5143<\/strong><\/p>\n<p>\u5317\u6d77\u9053\u5927\u5b66\u793e\u4f1a\u5171\u5275\u90e8\u5e83\u5831\u8ab2\uff08\u3012060-0808 \u672d\u5e4c\u5e02\u5317\u533a\u53178\u6761\u897f5\u4e01\u76ee\uff09<\/p>\n<p>\uff34\uff25\uff2c\u3000011-706-2610\u3000 \uff26\uff21\uff38\u3000011-706-2092\u3000 \u30e1\u30fc\u30eb\u3000jp-press@general.hokudai.ac.jp<\/p>\n<p><strong>\u3010\u53c2\u8003\u56f3\u3011<\/strong><\/p>\n<p><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f31.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6008\" src=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f31-1024x486.jpg\" alt=\"\" width=\"450\" height=\"214\" srcset=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f31-1024x486.jpg 1024w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f31-300x142.jpg 300w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f31-768x365.jpg 768w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f31.jpg 1658w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/a><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f32.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6009\" src=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f32-1024x386.jpg\" alt=\"\" width=\"450\" height=\"170\" srcset=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f32-1024x386.jpg 1024w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f32-300x113.jpg 300w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f32-768x289.jpg 768w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/06\/\u56f32.jpg 2012w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/a><\/p>\n<p><strong>\u3010\u7528\u8a9e\u89e3\u8aac\u3011<\/strong><\/p>\n<p>\uff0a1 \u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50 \u2026 \u7d30\u80de\u5185\u306b\u5b58\u5728\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u7a2e\u3002\u8907\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u540c\u6642\u306b\u7d50\u5408\u3059\u308b\u8db3\u5834\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3001\u7d30\u80de\u5185\u4fe1\u53f7\u4f1d\u9054\u306b\u95a2\u308f\u308b\u3002<\/p>\n<p>\uff0a2 ITAM\u30e2\u30c1\u30fc\u30d5\u2026 Immunoreceptor Tyrosine-based Activation Motifs\u306e\u7565\u3067\u3001CD3\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u306e\u7d30\u80de\u5185\u9818\u57df\u306b\u5b58\u5728\u3059\u308b\u30c1\u30ed\u30b7\u30f3\u6b8b\u57fa\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u3001\u7d30\u80de\u5185\u4fe1\u53f7\u4f1d\u9054\u3092\u5f15\u304d\u8d77\u3053\u3059\u5f15\u304d\u91d1\u3068\u306a\u308b\u7279\u5fb4\u7684\u306a\u30a2\u30df\u30ce\u9178\u4e00\u6b21\u914d\u5217\u3002<\/p>\n<p>\uff0a3 \u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u6cd5 \u2026 \u86cd\u5149\u6a19\u8b58\u3057\u305f\u6297\u4f53\u3092\u7d30\u80de\u306b\u7d50\u5408\u3055\u305b\u3001\u7d30\u80de\u4e00\u3064\u305a\u3064\u89e3\u6790\u3059\u308b\u65b9\u6cd5\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u304d\u308b\u3002<\/p>\n<p>\uff0a4 \u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u6cd5 \u2026 \u6297\u4f53\u3092\u7528\u3044\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u691c\u51fa\u3059\u308b\u65b9\u6cd5\u3002\u5206\u5b50\u91cf\u306a\u3069\u89e3\u6790\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n<p>\uff0a5 ELISA\u6cd5 \u2026 \u6297\u4f53\u3092\u7528\u3044\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u306a\u3069\u3092\u5b9a\u91cf\u3059\u308b\u65b9\u6cd5\u3002<\/p>\n<p>\uff0a6 \u514d\u75ab\u6c88\u964d\u6cd5 \u2026 \u6297\u4f53\u3092\u7528\u3044\u3066\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u3092\u89e3\u6790\u3059\u308b\u65b9\u6cd5\u3002<\/p>\n<p>\uff0a7 STAP-2\u6b20\u640d\u30de\u30a6\u30b9 \u2026 STAP-2\u907a\u4f1d\u5b50\u304c\u3042\u308b\u5834\u6240\u3092\u58ca\u3059\u3053\u3068\u3067\u3001STAP-2\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6b20\u5931\u3057\u3066\u3044\u308b\u30de\u30a6\u30b9\u3002<\/p>\n<p>\uff0a8 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3 \u2026 \u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u6db2\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u69d8\u3005\u306a\u751f\u7406\u6d3b\u6027\u4f5c\u7528\u3092\u6709\u3059\u308b\u3002<\/p>\n<p>\uff0a9 IFN-\u03b3 \u2026 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4e00\u7a2e\u3067\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u4e00\u90e8\u306eT\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3002\u514d\u75ab\u53ca\u3073\u708e\u75c7\u306e\u8abf\u7bc0\u6a5f\u80fd\u3092\u6709\u3059\u308b\u3002<\/p>\n<p>\uff0a10 IL-17 \u2026 \u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3002\u5c40\u6240\u3067\u7523\u751f\u3055\u308c\u308b\u3068\u3001\u597d\u4e2d\u7403\u3092\u5f15\u304d\u5bc4\u305b\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u5f15\u304d\u304a\u3053\u3059\u3002<\/p>\n<p>\uff0a11 2D2\u30de\u30a6\u30b9 \u2026 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