{"id":6296,"date":"2022-11-11T14:54:38","date_gmt":"2022-11-11T05:54:38","guid":{"rendered":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=6296"},"modified":"2022-11-11T14:54:38","modified_gmt":"2022-11-11T05:54:38","slug":"%e5%8a%b9%e7%8e%87%e7%9a%84%e3%81%aamrna%e9%80%81%e9%81%94%e3%82%92%e5%8f%af%e8%83%bd%e3%81%a8%e3%81%99%e3%82%8b%e5%88%86%e5%b2%90%e8%84%82%e8%b3%aa%e3%81%ae%e5%89%b5%e8%a3%bd%ef%bd%9emrna%e5%89%b5","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/6296.html","title":{"rendered":"\u52b9\u7387\u7684\u306amRNA\u9001\u9054\u3092\u53ef\u80fd\u3068\u3059\u308b\u5206\u5c90\u8102\u8cea\u306e\u5275\u88fd\uff5emRNA\u5275\u85ac\u3078\u306e\u8ca2\u732e\u306b\u671f\u5f85\uff5e\uff08\u85ac\u5b66\u7814\u7a76\u9662\u3000\u52a9\u6559\u3000\u4f50\u85e4\u60a0\u4ecb\uff09"},"content":{"rendered":"<p style=\"text-align: right;\">2022\u5e7411\u670811\u65e5<\/p>\n<p style=\"text-align: right;\">\u5317\u6d77\u9053\u5927\u5b66<br 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DDS\uff09\u304c\u5fc5\u9808\u3067\u3059\u3002mRNA\u7528DDS\u3068\u3057\u3066\u6700\u3082\u9032\u3093\u3067\u3044\u308b\u6280\u8853\u306f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3067\u3042\u308a\u3001\u4e0a\u8ff0\u306eCOVID-19\u30ef\u30af\u30c1\u30f3\u306b\u3082\u63a1\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u52b9\u7387\u7684\u306amRNA\u9001\u9054\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u3001\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u65b0\u898f\u306e\u5206\u5c90\u8102\u8cea\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u672c\u8102\u8cea\u304b\u3089\u4f5c\u88fd\u3055\u308c\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306f\u52b9\u7387\u7684\u306amRNA\u9001\u9054\u3068\u9ad8\u3044\u4fdd\u5b58\u5b89\u5b9a\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u306b\u3088\u308a\u3001\u5358\u56de\u6295\u4e0e\u3067\u306e\u52b9\u7387\u7684\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\u3084\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u672c\u8102\u8cea\u306e\u7279\u5fb4\u3067\u3042\u308b\u5206\u5c90\u69cb\u9020\u304c\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u6027\u80fd\u3068\u4fdd\u5b58\u5b89\u5b9a\u6027\u3092\u9ad8\u3081\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u958b\u767a\u3055\u308c\u305f\u5206\u5c90\u8102\u8cea\u304b\u3089\u69cb\u6210\u3055\u308c\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306emRNA\u533b\u85ac\u54c1\u3078\u306e\u5229\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u30012022\u5e7411\u670810\u65e5\uff08\u6728\uff09\u516c\u958b\u306eSmall Science\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u8ad6\u6587\u540d\uff1aBranching ionizable lipids can enhance the stability, fusogenicity, and functional delivery of mRNA\uff08\u30a4\u30aa\u30f3\u6027\u8102\u8cea\u306e\u5206\u5c90\u8db3\u5834\u306f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u5b89\u5b9a\u6027\u3068in vivo mRNA\u9001\u9054\u52b9\u7387\u3092\u9ad8\u3081\u308b\uff09<br \/>\nURL\uff1a<a href=\"https:\/\/doi.org\/10.1002\/smsc.202200071\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1002\/smsc.202200071<\/a><\/p>\n<p>\u8a73\u7d30\u306f<a href=\"https:\/\/www.hokudai.ac.jp\/news\/pdf\/221111_pr.pdf\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a><\/p>\n<p><a href=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/11\/\u85ac\u5b66\u7528\u6249\u7d75.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-6297\" src=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/11\/\u85ac\u5b66\u7528\u6249\u7d75-300x218.jpg\" alt=\"\" width=\"300\" height=\"218\" srcset=\"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/11\/\u85ac\u5b66\u7528\u6249\u7d75-300x218.jpg 300w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/11\/\u85ac\u5b66\u7528\u6249\u7d75-768x559.jpg 768w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/11\/\u85ac\u5b66\u7528\u6249\u7d75-1024x745.jpg 1024w, https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-content\/uploads\/2022\/11\/\u85ac\u5b66\u7528\u6249\u7d75.jpg 1304w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>2022\u5e7411\u670811\u65e5 \u5317\u6d77\u9053\u5927\u5b66 \u65e5\u6771\u96fb\u5de5\u682a\u5f0f\u4f1a\u793e \u30dd\u30a4\u30f3\u30c8 \u25cfmRNA\u306e\u533b\u85ac\u54c1\u5fdc\u7528\u306b\u6b20\u304b\u305b\u306a\u3044\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3092\u69cb\u6210\u3059\u308b\u65b0\u898f\u306e\u5206\u5c90\u578b\u8102\u8cea\u3092\u5171\u540c\u958b\u767a\u3002 \u25cf\u5206\u5c90\u8102\u8cea\u306f\u52b9\u7387\u7684\u306amRNA\u9001\u9054\u3092\u53ef\u80fd\u3068\u3057\u3001\u5358\u56de\u6295\u4e0e\u3067\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-6296","post","type-post","status-publish","format-standard","hentry","category-sci"],"_links":{"self":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/comments?post=6296"}],"version-history":[{"count":1,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6296\/revisions"}],"predecessor-version":[{"id":6298,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6296\/revisions\/6298"}],"wp:attachment":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/media?parent=6296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/categories?post=6296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/tags?post=6296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}