{"id":6358,"date":"2022-12-06T10:38:11","date_gmt":"2022-12-06T01:38:11","guid":{"rendered":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=6358"},"modified":"2022-12-06T15:38:55","modified_gmt":"2022-12-06T06:38:55","slug":"%e6%96%b0%e8%a6%8f%e3%83%9a%e3%83%97%e3%83%81%e3%83%89%e9%98%bb%e5%ae%b3%e5%89%a4%e3%82%88%e3%82%8b%e8%85%ab%e7%98%8d%e5%bd%a2%e6%88%90%e9%98%bb%e6%ad%a2%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/6358.html","title":{"rendered":"\u65b0\u898f\u30da\u30d7\u30c1\u30c9\u963b\u5bb3\u5264\u3088\u308b\u816b\u760d\u5f62\u6210\u963b\u6b62\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\uff5eEGFR\u767a\u73fe\u4e0a\u76ae\u7cfb\u304c\u3093\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u85ac\u958b\u767a\u306b\u671f\u5f85\uff5e\uff08\u85ac\u5b66\u7814\u7a76\u9662\u3000\u52a9\u6559\u3000\u935b\u4ee3\u60a0\u4e00\u3001\u6559\u6388\u3000\u677e\u7530\u3000\u6b63\uff09"},"content":{"rendered":"

\u30dd\u30a4\u30f3\u30c8<\/h3>\n

\u25cfEGFR\u3068STAP-2\u306e\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u3092\u963b\u5bb3\u3059\u308bSTAP-2\u7531\u67652D5\u30da\u30d7\u30c1\u30c9\u3092\u540c\u5b9a\u3002
\n\u25cfSTAP-2\u7531\u67652D5\u30da\u30d7\u30c1\u30c9\u306fEGFR\u4f9d\u5b58\u7684\u306a\u304c\u3093\u7d30\u80de\u5897\u6b96\u3084\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u816b\u760d\u5f62\u6210\u3092\u963b\u5bb3\u3002
\n\u25cfSTAP-2\u7531\u67652D5\u30da\u30d7\u30c1\u30c92D5\u306e\u5fdc\u7528\u304c\u65b0\u3057\u3044\u304c\u3093\u6cbb\u7642\u85ac\u958b\u767a\u306b\u7e4b\u304c\u308b\u3053\u3068\u306b\u671f\u5f85\u3002<\/p>\n

\u6982\u8981<\/h3>\n

\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u306e\u935b\u4ee3\u60a0\u4e00\u52a9\u6559\u3001\u677e\u7530\u3000\u6b63\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u7a2e\u3005\u306e\u4e0a\u76ae\u7cfb\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u3092\u5236\u5fa1\u3059\u308b\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bSignal-transducing adaptor protein-2\uff08STAP-2\uff09\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u92f3\u578b\u306b\u3057\u305f2D5\u963b\u5bb3\u30da\u30d7\u30c1\u30c9\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u4e0a\u76ae\u7cfb\u304c\u3093\u7d30\u80de\u8868\u9762\u306e\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f53\uff08EGFR\uff09\u306f\u3001\u304c\u3093\u7d30\u80de\u5897\u6b96\u306e\u30b9\u30a4\u30c3\u30c1\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u30022D5\u30da\u30d7\u30c1\u30c9\u306f\u3001STAP-2\u306e\u4f5c\u7528\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u3067\u3001EGFR\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u3001\u304c\u3093\u7d30\u80de\u5897\u6b96\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u30022D5\u963b\u5bb3\u30da\u30d7\u30c1\u30c9\u306e\u3055\u3089\u306a\u308b\u5fdc\u7528\u306b\u3088\u308a\u3001\u65b0\u3057\u3044\u6297\u304c\u3093\u5264\u958b\u767a\u306b\u7e4b\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f2022\u5e7411\u670819\u65e5\uff08\u571f\uff09\u516c\u958b\u306eThe Journal of Biological Chemistry\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u8ad6\u6587\u540d\uff1aA peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling\uff08STAP-2\u7531\u6765\u30da\u30d7\u30c1\u30c9\u306fEGFR\u30b7\u30b0\u30ca\u30eb\u3092\u5236\u5fa1\u3057\u3066\u816b\u760d\u5f62\u6210\u3092\u963b\u5bb3\u3059\u308b\uff09
\nURL\uff1ahttps:\/\/doi.org\/10.1016\/j.jbc.2022.102724<\/a><\/p>\n

\u8a73\u7d30\u306f\u3053\u3061\u3089<\/a><\/p>\n

<\/a>
\n\u30b7\u30b0\u30ca\u30eb\u5206\u5b50STAP-2\u3068\u304c\u3093\u3068\u306e\u95a2\u9023\u3068\u672c\u7814\u7a76\u306b\u3088\u308b\u65b0\u305f\u306a\u304c\u3093\u6cbb\u7642\u6226\u7565\u3078\u306e\u5c55\u958b<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30dd\u30a4\u30f3\u30c8 \u25cfEGFR\u3068STAP-2\u306e\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u3092\u963b\u5bb3\u3059\u308bSTAP-2\u7531\u67652D5\u30da\u30d7\u30c1\u30c9\u3092\u540c\u5b9a\u3002 \u25cfSTAP-2\u7531\u67652D5\u30da\u30d7\u30c1\u30c9\u306fEGFR\u4f9d\u5b58\u7684\u306a\u304c\u3093\u7d30\u80de\u5897\u6b96\u3084\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u816b\u760d\u5f62\u6210\u3092\u963b\u5bb3\u3002 \u25cfSTAP-2\u7531\u67652D5 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-6358","post","type-post","status-publish","format-standard","hentry","category-sci"],"_links":{"self":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/comments?post=6358"}],"version-history":[{"count":2,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6358\/revisions"}],"predecessor-version":[{"id":6362,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6358\/revisions\/6362"}],"wp:attachment":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/media?parent=6358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/categories?post=6358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/tags?post=6358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}