{"id":6437,"date":"2023-02-17T09:47:50","date_gmt":"2023-02-17T00:47:50","guid":{"rendered":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=6437"},"modified":"2023-02-17T09:47:50","modified_gmt":"2023-02-17T00:47:50","slug":"%e5%8a%b9%e7%8e%87%e7%9a%84%e3%81%aa%e3%82%b2%e3%83%8e%e3%83%a0%e7%b7%a8%e9%9b%86%e3%82%92%e5%8f%af%e8%83%bd%e3%81%a8%e3%81%99%e3%82%8b%e8%84%82%e8%b3%aa%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%e3%81%ae","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/6437.html","title":{"rendered":"\u52b9\u7387\u7684\u306a\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u53ef\u80fd\u3068\u3059\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u958b\u767a\uff5e\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u3078\u306e\u8ca2\u732e\u306b\u671f\u5f85\uff5e\uff08\u85ac\u5b66\u7814\u7a76\u9662\u3000\u52a9\u6559\u3000\u4f50\u85e4\u60a0\u4ecb\uff09"},"content":{"rendered":"

\u30dd\u30a4\u30f3\u30c8<\/h3>\n

\u25cf\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u306e\u5b9f\u73fe\u306b\u6b20\u304b\u305b\u306a\u3044\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u88fd\u5264\u8a2d\u8a08\u65b9\u6cd5\u3092\u78ba\u7acb\u3002
\n\u25cfRNP\u306e\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3078\u306e\u52b9\u7387\u7684\u306a\u642d\u8f09\u3068\u7d30\u80de\u5185\u3067\u306eRNP\u306e\u30ea\u30ea\u30fc\u30b9\u306e\u4e21\u7acb\u306e\u91cd\u8981\u6027\u3092\u89e3\u660e\u3002
\n\u25cfCRISPR-LNP\u306e\u9759\u8108\u5185\u6295\u4e0e\u306b\u3088\u308a\u809d\u81d3\u907a\u4f1d\u5b50\u306e80%\u4ee5\u4e0a\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3092\u9054\u6210\u3002<\/p>\n

\u6982\u8981<\/h3>\n

\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u306e\u4f50\u85e4\u60a0\u4ecb\u52a9\u6559\u3001\u539f\u5cf6\u79c0\u5409\u6559\u6388\u3001\u540c\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u9662\u4fee\u58eb\u8ab2\u7a0b\u306e\u5c0f\u6cbc\u306f\u308b\u306e\u6c0f\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u52b9\u7387\u7684\u306a\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u53ef\u80fd\u3068\u3059\u308b\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff08Lipid Nanoparticles: LNPs\uff09\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n

2020\u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u306e\u5bfe\u8c61\u3068\u306a\u3063\u305fCRISPR\/Cas\u30b7\u30b9\u30c6\u30e0\u306f\u3001\u591a\u69d8\u306a\u96e3\u6cbb\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6839\u672c\u7684\u6cbb\u7642\u6226\u7565\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u305d\u306e\u533b\u85ac\u54c1\u5fdc\u7528\u306e\u305f\u3081\u306b\u306f\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb\u3092\u6a19\u7684\u7d44\u7e54\u3060\u3051\u306b\u5b89\u5168\u304b\u3064\u52b9\u7387\u7684\u306b\u9001\u9054\u3059\u308b\u6280\u8853\u304c\u5fc5\u8981\u4e0d\u53ef\u6b20\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n

LNP\u306f\u85ac\u7269\u306e\u4f53\u5185\u52d5\u614b\u3092\u5236\u5fa1\u3059\u308b\u6280\u8853\uff08Drug delivery system: DDS\uff09\u306e\u4e00\u3064\u3067\u3059\u3002\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u308c\u307e\u3067\u306b\u3001CRISPR\/Cas9\u30bf\u30f3\u30d1\u30af\u8cea-RNA\u8907\u5408\u4f53\uff08ribonucleoprotein: RNP\uff09\u3092\u4e00\u672c\u9396\u30aa\u30ea\u30b4DNA\uff08ssODN\uff09\u3068\u8907\u5408\u4f53\u5316\u3055\u305bLNP\u306b\u5c01\u5165\u3057\u305f\u88fd\u5264\uff08CRISPR-LNP\uff09\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u3001\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7d30\u80de\u8cea\u5185\u9001\u9054\u5f8c\u306eRNP\u306essODN\u304b\u3089\u306e\u30ea\u30ea\u30fc\u30b9\u306b\u7740\u76ee\u3057\u3001\u6700\u9069\u306assODN\u306e\u8a2d\u8a08\u65b9\u6cd5\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u6700\u9069\u5316\u3055\u308c\u305fCRISPR-LNP\u306e\u9759\u8108\u5185\u6295\u4e0e\u306b\u3088\u308a\u3001\u809d\u81d3\u907a\u4f1d\u5b50\u306e80\uff05\u4ee5\u4e0a\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u958b\u767a\u3055\u308c\u305f\u6700\u9069ssODN\u306e\u8a2d\u8a08\u306b\u57fa\u3065\u3044\u305fCRISPR-LNP\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u3078\u306e\u5b9f\u7528\u5316\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u30012023\u5e742\u670810\u65e5\uff08\u91d1\uff09\u516c\u958b\u306eJournal of Controlled Release\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u8ad6\u6587\u540d\uff1aLipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing\uff08in vivo\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u76ee\u6307\u3057\u305f\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u30d9\u30fc\u30b9\u306eRNP\u9001\u9054\uff09
\nURL\uff1ahttps:\/\/doi.org\/10.1016\/j.jconrel.2023.02.008<\/a><\/p>\n

\u8a73\u7d30\u306f\u3053\u3061\u3089<\/a><\/p>\n

<\/a>
\n\u672c\u7814\u7a76\u306e\u6982\u8981\u56f3<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30dd\u30a4\u30f3\u30c8 \u25cf\u30b2\u30ce\u30e0\u7de8\u96c6\u6cbb\u7642\u306e\u5b9f\u73fe\u306b\u6b20\u304b\u305b\u306a\u3044\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u306e\u88fd\u5264\u8a2d\u8a08\u65b9\u6cd5\u3092\u78ba\u7acb\u3002 \u25cfRNP\u306e\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\u3078\u306e\u52b9\u7387\u7684\u306a\u642d\u8f09\u3068\u7d30\u80de\u5185\u3067\u306eRNP\u306e\u30ea\u30ea\u30fc\u30b9\u306e\u4e21\u7acb\u306e\u91cd\u8981\u6027\u3092\u89e3\u660e\u3002 \u25cfCRISPR-LNP\u306e\u9759\u8108\u5185\u6295\u4e0e\u306b\u3088\u308a\u809d\u81d3\u907a\u4f1d\u5b50 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-6437","post","type-post","status-publish","format-standard","hentry","category-sci"],"_links":{"self":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/comments?post=6437"}],"version-history":[{"count":1,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6437\/revisions"}],"predecessor-version":[{"id":6439,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6437\/revisions\/6439"}],"wp:attachment":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/media?parent=6437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/categories?post=6437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/tags?post=6437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}