{"id":6630,"date":"2023-07-03T13:53:46","date_gmt":"2023-07-03T04:53:46","guid":{"rendered":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=6630"},"modified":"2023-07-03T13:53:46","modified_gmt":"2023-07-03T04:53:46","slug":"%e7%b5%90%e6%a0%b8%e8%8f%8c%e7%b3%96%e8%84%82%e8%b3%aa%e3%81%ae%e5%85%8d%e7%96%ab%e5%8f%97%e5%ae%b9%e4%bd%93mincle%e3%81%ab%e3%82%88%e3%82%8b%e8%aa%8d%e8%ad%98%e6%a9%9f%e6%a7%8b%e3%81%ae%e8%a7%a3","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/6630.html","title":{"rendered":"\u7d50\u6838\u83cc\u7cd6\u8102\u8cea\u306e\u514d\u75ab\u53d7\u5bb9\u4f53Mincle\u306b\u3088\u308b\u8a8d\u8b58\u6a5f\u69cb\u306e\u89e3\u660e\u301c\u30ef\u30af\u30c1\u30f3\u958b\u767a\u306b\u91cd\u8981\u306a\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u306e\u52b9\u7387\u7684\u306a\u958b\u767a\u3078\u306e\u8ca2\u732e\u306b\u671f\u5f85\uff5e\uff08\u85ac\u5b66\u7814\u7a76\u9662\u3000\u6559\u6388\u3000\u524d\u4ef2\u52dd\u5b9f\uff09"},"content":{"rendered":"<h3>\u30dd\u30a4\u30f3\u30c8<\/h3>\n<p>\u25cfNMR\u6cd5\u3092\u7528\u3044\u3066\u3001Mincle\u306e\u7cd6\u8102\u8cea\u8a8d\u8b58\u6a5f\u69cb\u3092\u89e3\u660e\u3002<br \/>\n\u25cfMincle\u306e\u7cd6\u8102\u8cea\u8a8d\u8b58\u90e8\u4f4d\u306f\u63fa\u3089\u3044\u3060\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3002<br \/>\n\u25cf\u52b9\u679c\u7684\u306a\u514d\u75ab\u8ce6\u6d3b\u5264\uff08\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\uff09\u306e\u958b\u767a\u306b\u671f\u5f85\u3002<\/p>\n<h3>\u6982\u8981<\/h3>\n<p>\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u306e\u524d\u4ef2\u52dd\u5b9f\u6559\u6388\u3001\u53e4\u5ddd\u3000\u6566\u52a9\u6559\uff08\u73fe\u30fb\u91d1\u6ca2\u5927\u5b66\u533b\u85ac\u4fdd\u5065\u7814\u7a76\u57df\u85ac\u5b66\u7cfb\u51c6\u6559\u6388\uff09\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5317\u6d77\u9053\u79d1\u5b66\u5927\u5b66\u85ac\u5b66\u90e8\u306e\u9f4a\u85e4\u8cb4\u58eb\u51c6\u6559\u6388\u3001\u5927\u962a\u5927\u5b66\u5fae\u751f\u7269\u75c5\u7814\u7a76\u6240\u306e\u5c71\u5d0e\u3000\u6676\u6559\u6388\u3089\u3068\u5171\u540c\u3067\u3001\u514d\u75ab\u8ce6\u6d3b\u5264\uff08\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\uff09\u3068\u306a\u308b\u7d50\u6838\u83cc\u306e\u8868\u9762\u306b\u5b58\u5728\u3059\u308b\u30c8\u30ec\u30cf\u30ed\u30fc\u30b9\u30b8\u30de\u30a4\u30b3\u30ec\u30fc\u30c8\uff08TDM\uff09\u306a\u3069\u5e45\u5e83\u3044\u7cd6\u8102\u8cea\u3092\u8a8d\u8b58\u3057\u3001\u514d\u75ab\u306e\u6d3b\u6027\u5316\u306b\u95a2\u308f\u308bMincle\u306e\u7cd6\u8102\u8cea\u8a8d\u8b58\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>Mincle\uff08Macrophage inducible C-type lectin\uff09\u306f\u514d\u75ab\u7d30\u80de\u306e\u8868\u9762\u306b\u767a\u73fe\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u7d50\u6838\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u77e5\u3089\u308c\u308bBCG\u30ef\u30af\u30c1\u30f3\u306b\u542b\u307e\u308c\u3001\u514d\u75ab\u6d3b\u6027\u5316\u52b9\u679c\u306e\u3042\u308b\u7d50\u6838\u83cc\u7531\u6765\u306e\u7cd6\u8102\u8cea\u3068Mincle\u304c\u7d50\u5408\u3057\u3066\u514d\u75ab\u6d3b\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u75c5\u539f\u4f53\u3092\u6392\u9664\u3057\u307e\u3059\u3002\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3053\u308c\u307e\u3067\u306bX\u7dda\u3092\u7528\u3044\u3066Mincle\u306e\u7d50\u6676\u69cb\u9020\u3092\u89e3\u660e\u3057\u3001\u7cd6\u8102\u8cea\u8a8d\u8b58\u6a5f\u69cb\u3092\u63a8\u5b9a\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u7cd6\u8102\u8cea\u304c\u7d50\u5408\u3057\u305fMincle\u306e\u69cb\u9020\u3084\u3001Mincle\u304c\u7cd6\u8102\u8cea\u3092\u8a8d\u8b58\u3059\u308b\u6a5f\u5e8f\u306f\u4e0d\u660e\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001Nuclear Magnetic Resonance\uff08NMR\uff09\u6cd5\u3092\u7528\u3044\u3066\u3001Mincle\u306e\u7cd6\u8102\u8cea\u8a8d\u8b58\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>NMR\u6cd5\u306b\u3088\u3063\u3066Mincle\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7acb\u4f53\u69cb\u9020\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u6eb6\u6db2\u4e2d\u306eMincle\u306f\u3001\u63fa\u3089\u304e\u304c\u5927\u304d\u3044\u69cb\u9020\u3092\u53d6\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u89e3\u660e\u3055\u308c\u307e\u3057\u305f\u3002Mincle\u306e\u7cd6\u8102\u8cea\u306e\u7d50\u5408\u90e8\u4f4d\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u6c34\u6eb6\u6027\u306e\u9ad8\u30441\u672c\u9396\u306e\u8102\u8cea\u3092\u6301\u3064\u7cd6\u8102\u8cea\u3092\u6ef4\u4e0b\u3057\u3001Mincle\u306e\u5316\u5b66\u30b7\u30d5\u30c8\u5909\u5316\u3092\u89b3\u6e2c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u7cd6\u8102\u8cea\u306e\u7d50\u5408\u306b\u3088\u308a\u3001\u7cd6\u306e\u7d50\u5408\u90e8\u4f4d\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u5e45\u5e83\u3044\u7bc4\u56f2\u306e\u30a2\u30df\u30ce\u9178\u3067\u5316\u5b66\u30b7\u30d5\u30c8\u5909\u5316\u3092\u793a\u3059\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u7cd6\u90e8\u5206\u306e\u307f\u306e\u6dfb\u52a0\u3067\u306f\u3001\u7cd6\u8102\u8cea\u307b\u3069\u5e83\u7bc4\u56f2\u306e\u30a2\u30df\u30ce\u9178\u3067\u306e\u5316\u5b66\u30b7\u30d5\u30c8\u5909\u5316\u306f\u8d77\u3053\u3089\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u8102\u8cea\u306e\u7d50\u5408\u90e8\u4f4d\u304c\u5e83\u7bc4\u306b\u6e21\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3057\u305f\u3002Mincle\u3092\u4ecb\u3057\u305f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u80fd\u304c\u5f37\u30442\u672c\u9396\u306e\u8102\u8cea\u3067\u3082\u540c\u69d8\u306e\u7d50\u679c\u304bELISA\u6cd5\u3092\u7528\u3044\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u30012\u672c\u9396\u306e\u7cd6\u8102\u8cea\u306e\u7d50\u5408\u3067\u306f\u3001\u8102\u8cea\u90e8\u5206\u306e\u7d50\u54081\u672c\u9396\u3067\u7d50\u5408\u306b\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u305f\u30a2\u30df\u30ce\u9178\u306b\u52a0\u3048\u3001\u4ed6\u306e\u30a2\u30df\u30ce\u9178\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u30012\u672c\u9396\u306e\u8102\u8cea\u90e8\u5206\u306b\u7d50\u5408\u3057\u305f\u90e8\u4f4d\u306b\u5316\u5408\u7269\u304c\u7d50\u5408\u3059\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3059\u308b\u3053\u3068\u304c\u3001\u52b9\u679c\u7684\u306a\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u306e\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u30012023\u5e746\u670821\u65e5\uff08\u6c34\uff09\u516c\u958b\u306eStructure\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u8ad6\u6587\u540d\uff1aStructural basis for glycolipid recognition of the C-type lectin Mincle\uff08C\u578b\u30ec\u30af\u30c1\u30f3\u53d7\u5bb9\u4f53Mincle\u306e\u7cd6\u8102\u8cea\u8a8d\u8b58\u306e\u69cb\u9020\u5b66\u7684\u57fa\u76e4\uff09<br \/>\nURL\uff1a<a href=\"https:\/\/doi.org\/10.1016\/j.str.2023.05.018\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.str.2023.05.018<\/a><\/p>\n<p>\u8a73\u7d30\u306f<a href=\"https:\/\/www.hokudai.ac.jp\/news\/pdf\/230626_pr.pdf\" target=\"_blank\" rel=\"noopener\">\u3053\u3061\u3089<\/a><\/p>\n<p><a href=\"https:\/\/www.hokudai.ac.jp\/news\/img\/230626_pr_pic.jpg\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.hokudai.ac.jp\/news\/img\/230626_pr_pic.jpg\" width=\"400\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30dd\u30a4\u30f3\u30c8 \u25cfNMR\u6cd5\u3092\u7528\u3044\u3066\u3001Mincle\u306e\u7cd6\u8102\u8cea\u8a8d\u8b58\u6a5f\u69cb\u3092\u89e3\u660e\u3002 \u25cfMincle\u306e\u7cd6\u8102\u8cea\u8a8d\u8b58\u90e8\u4f4d\u306f\u63fa\u3089\u3044\u3060\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3002 \u25cf\u52b9\u679c\u7684\u306a\u514d\u75ab\u8ce6\u6d3b\u5264\uff08\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\uff09\u306e\u958b\u767a\u306b\u671f\u5f85\u3002 \u6982\u8981 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-6630","post","type-post","status-publish","format-standard","hentry","category-sci"],"_links":{"self":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/comments?post=6630"}],"version-history":[{"count":1,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6630\/revisions"}],"predecessor-version":[{"id":6632,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6630\/revisions\/6632"}],"wp:attachment":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/media?parent=6630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/categories?post=6630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/tags?post=6630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}