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\u30dd\u30a4\u30f3\u30c8<\/h3>\n

\u25cf\u514d\u75ab\u5fdc\u7b54\u3092\u62c5\u3046T\u7d30\u80de\u5185\u306eSTAP-2\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u898f\u963b\u5bb3\u5264\u306e\u958b\u767a\u3002
\n\u25cf\u672c\u963b\u5bb3\u5264\u306e\u51e6\u7406\u306b\u3088\u308bT\u7d30\u80de\u6d3b\u6027\u5316\u3068\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u5897\u60aa\u5316\u6291\u5236\u3002
\n\u25cf\u65b0\u305f\u306a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u958b\u767a\u306b\u671f\u5f85\u3002<\/p>\n

\u6982\u8981<\/h3>\n

\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u306e\u4f50\u3005\u6728\u60a0\u6597\u7814\u7a76\u54e1\u3001\u677e\u7530\u3000\u6b63\u6559\u6388\u53ca\u3073\u5317\u6d77\u9053\u79d1\u5b66\u5927\u5b66\u306e\u67cf\u5009\u6df3\u4e00\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30a2\u30c0\u30d7\u30bf\u30fc\u5206\u5b50\u3067\u3042\u308bSTAP-2\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u305f\u306aT\u7d30\u80de\u963b\u5bb3\u5264\u3092\u958b\u767a\u3057\u3001\u672c\u963b\u5bb3\u5264\u304c\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u75c5\u614b\u3092\u6291\u5236\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u901a\u5e38\u3067\u306f\u30d2\u30c8\u306e\u4f53\u5185\u306b\u75c5\u539f\u4f53\u304c\u4fb5\u5165\u3057\u305f\u5834\u5408\u3001\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u304c\u62c5\u3046\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u306b\u3088\u308a\u6392\u9664\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u53cd\u5fdc\u306b\u306fT\u7d30\u80de\u304c\u4e3b\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001T\u7d30\u80de\u306e\u6a5f\u80fd\u306fT\u7d30\u80de\u53d7\u5bb9\u4f53\uff08TCR\u3001T cell receptor\uff09\u4e0b\u6d41\u306e\u4fe1\u53f7\u4f1d\u9054\u6a5f\u69cb\u306b\u3088\u308a\u3001\u53b3\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f55\u3089\u304b\u306e\u539f\u56e0\u306b\u3088\u308bT\u7d30\u80de\u7570\u5e38\u6d3b\u6027\u5316\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u767a\u75c7\u3084\u91cd\u75c7\u5316\u306e\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001TCR\u3092\u4ecb\u3057\u305f\u4fe1\u53f7\u4f1d\u9054\u6a5f\u69cb\u306e\u89e3\u660e\u53ca\u3073\u5236\u5fa1\u304c\u3001\u514d\u75ab\u75be\u60a3\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\u306f\u91cd\u8981\u3067\u3059\u3002<\/p>\n

\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u4ee5\u524d\u3001\u305d\u306e\u4fe1\u53f7\u4f1d\u9054\u306b\u306fSTAP-2\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u89e3\u660e\u3057\u3001STAP-2\u304cTCR\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8ceaCD3\u03b6\u3068\u76f4\u63a5\u7d50\u5408\u3057\u3066\u305d\u306e\u50cd\u304d\u3092\u5f37\u3081\u308b\u3053\u3068\u306b\u3088\u308a\u3001T\u7d30\u80de\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u305d\u306e\u767a\u898b\u3092\u5fdc\u7528\u3057\u3001STAP-2\/CD3\u03b6\u306e\u7d50\u5408\u963b\u5bb3\u306b\u3088\u3063\u3066T\u7d30\u80de\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u30b3\u30f3\u30bb\u30d7\u30c8\u306e\u3082\u3068\u672c\u963b\u5bb3\u30da\u30d7\u30c1\u30c9\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u963b\u5bb3\u30da\u30d7\u30c1\u30c9\u306b\u3088\u3063\u3066T\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u5b9f\u969b\u306b\u6291\u5236\u3055\u308c\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u75c5\u614b\u3082\u8efd\u6e1b\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u963b\u5bb3\u30da\u30d7\u30c1\u30c9\u3092\u3055\u3089\u306b\u6700\u9069\u5316\u3057\u3001\u81e8\u5e8a\u3078\u306e\u5fdc\u7528\u3092\u9032\u3081\u308b\u3053\u3068\u3067\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u65b0\u305f\u306a\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n

\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u96d1\u8a8cThe Journal of Immunology\u30672023\u5e747\u67087\u65e5\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u8ad6\u6587\u540d\uff1aSTAP-2-derived peptide suppresses T cell receptor-mediated signals to initiate immune responses (STAP-2\u7531\u6765\u306e\u30da\u30d7\u30c1\u30c9\u306fT\u7d30\u80de\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u514d\u75ab\u53cd\u5fdc\u3092\u6291\u5236\u3059\u308b)
\nURL\uff1ahttps:\/\/doi.org\/10.4049\/jimmunol.2200942<\/a><\/p>\n

\u8a73\u7d30\u306f\u3053\u3061\u3089<\/a><\/p>\n

<\/a>
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