{"id":6779,"date":"2023-11-01T12:27:01","date_gmt":"2023-11-01T03:27:01","guid":{"rendered":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/?p=6779"},"modified":"2023-11-01T12:27:01","modified_gmt":"2023-11-01T03:27:01","slug":"%e3%83%87%e3%83%b3%e3%82%b0%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e3%82%84%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e7%ad%89%e3%81%ae%e5%a2%97%e6%ae%96%e3%82%92","status":"publish","type":"post","link":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/6779.html","title":{"rendered":"\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u3084\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u7b49\u306e\u5897\u6b96\u3092\u6291\u3048\u308b\u5e83\u57df\u963b\u5bb3\u85ac\u3092\u767a\u898b\uff5e\u30c7\u30f3\u30b0\u71b1\u7b49\u306e\u65b0\u8208\u30fb\u518d\u8208\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u6cbb\u7642\u85ac\u958b\u767a\u306b\u671f\u5f85\uff5e\uff08\u85ac\u5b66\u7814\u7a76\u9662\u3000\u6559\u6388\u3000\u524d\u4ef2\u52dd\u5b9f\uff09"},"content":{"rendered":"

\u30dd\u30a4\u30f3\u30c8<\/h3>\n

\u25cf\u5317\u5927\u5275\u85ac\u79d1\u5b66\u7814\u7a76\u6559\u80b2\u30bb\u30f3\u30bf\u30fc\u306e\u6838\u9178\u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u7528\u3044\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u5b9f\u65bd\u3002
\n\u25cf\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u3084\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3092\u542b\u3080\u8907\u6570\u306e\u30a6\u30a4\u30eb\u30b9\u7a2e\u306b\u5bfe\u3057\u3066\u5f37\u529b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3059s2U\u3092\u540c\u5b9a\u3002
\n\u25cf\u30c7\u30f3\u30b0\u71b1\u7b49\u306e\u6cbb\u7642\u85ac\u306e\u306a\u3044\u65b0\u8208\u30fb\u518d\u8208\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u5e83\u57df\u7684\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u958b\u767a\u306b\u671f\u5f85\u3002<\/p>\n

\u6982\u8981<\/h3>\n

\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u306e\u524d\u4ef2\u52dd\u5b9f\u6559\u6388\u3001\u540c\u5927\u5b66\u306e\u677e\u7530\u3000\u5f70\u540d\u8a89\u6559\u6388\u3001\u540c\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u9662\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b\uff08\u5f53\u6642\uff09\u306e\u4e0a\u6751\u5065\u592a\u6717\u6c0f\uff08\u73fe\uff1a\u5927\u962a\u5927\u5b66\u611f\u67d3\u75c7\u7dcf\u5408\u6559\u80b2\u7814\u7a76\u62e0\u70b9 \u7279\u4efb\u52a9\u6559\uff09\u3001\u540c\u5927\u5b66\u4eba\u7363\u5171\u901a\u611f\u67d3\u75c7\u56fd\u969b\u5171\u540c\u7814\u7a76\u6240\u306e\u6fa4\u3000\u6d0b\u6587\u6559\u6388\uff08\u5f53\u6642\u3001\u73fe\uff1a\u540c\u5927\u5b66\u5275\u6210\u7814\u7a76\u6a5f\u69cb\u30ef\u30af\u30c1\u30f3\u7814\u7a76\u958b\u767a\u62e0\u70b9 \u6559\u6388\uff09\u3068\u4f50\u85e4\u5f70\u5f66\u5ba2\u54e1\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u30012-Thiouridine\uff08s2U\uff09\u304c\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\uff08DENV\uff09\u3084\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u7b49\u306b\u5bfe\u3057\u3066\u5f37\u529b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u672c\u7814\u7a76\u3067\u7279\u306b\u7740\u76ee\u3057\u305fDENV\u306f\u3001\u3053\u308c\u307e\u3067\u591a\u304f\u306e\u30ef\u30af\u30c1\u30f3\u53ca\u3073\u6cbb\u7642\u85ac\u306e\u958b\u767a\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u672a\u3060\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u65b0\u305f\u306a\u6cbb\u7642\u85ac\u5019\u88dc\u306e\u63a2\u7d22\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u540c\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u5275\u85ac\u79d1\u5b66\u7814\u7a76\u6559\u80b2\u30bb\u30f3\u30bf\u30fc\u306e\u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u7528\u3044\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u5b9f\u65bd\u3057\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u6709\u3059\u308b\u6838\u9178\u4ee3\u8b1d\u62ee\u6297\u85ac\u306e\u540c\u5b9a\u3092\u8a66\u307f\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u7d30\u80de\u306b\u5bfe\u3057\u3066\u5f37\u3044\u6bd2\u6027\u3092\u793a\u3059\u3053\u3068\u306a\u304f\u3001DENV\u3084SARS-CoV-2\u3092\u542b\u3080\u8907\u6570\u306e\u30a6\u30a4\u30eb\u30b9\u7a2e\u306b\u5bfe\u3057\u3066\u5f37\u529b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u6709\u3059\u308bs2U\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u672c\u5316\u5408\u7269\u306f\u5e02\u4e2d\u306b\u6d41\u884c\u3057\u3066\u3044\u308b\u30aa\u30df\u30af\u30ed\u30f3\u682a\u306b\u5bfe\u3057\u3066\u3082\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u7d9a\u3044\u3066\u3001\u672c\u5316\u5408\u7269\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001\u672c\u5316\u5408\u7269\u306f\u30a6\u30a4\u30eb\u30b9\u306eRNA\u4f9d\u5b58\u6027RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\uff08RdRp\uff09\u306b\u3088\u308a\u5a92\u4ecb\u3055\u308c\u308b\u30a6\u30a4\u30eb\u30b9RNA\u306e\u5408\u6210\u4f38\u9577\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u52a0\u3048\u3066\u3001\u5b9f\u9a13\u52d5\u7269\u3092\u7528\u3044\u305f\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u5b9f\u9a13\u306e\u7d50\u679c\u304b\u3089\u3001\u672c\u5316\u5408\u7269\u306e\u6295\u4e0e\u306b\u3088\u308a\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u75c7\u72b6\u6539\u5584\uff08\u81f4\u6b7b\u6291\u5236\u52b9\u679c\uff09\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30d2\u30c8\u306b\u91cd\u7be4\u306a\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059DENV\u7b49\u306e\u868a\u5a92\u4ecb\u6027\u30a6\u30a4\u30eb\u30b9\u3084\u3001SARS-CoV-2\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u7b49\u3001\u5e45\u5e83\u3044\u30a6\u30a4\u30eb\u30b9\u7a2e\u306b\u5bfe\u3057\u3066\u672c\u5316\u5408\u7269\u304c\u5f37\u529b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002DENV\u7b49\u306e\u65b0\u8208\u30fb\u518d\u8208\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u6709\u52b9\u304b\u3064\u5b89\u5168\u306a\u6cbb\u7642\u85ac\u306f\u5b58\u5728\u3057\u306a\u3044\u305f\u3081\u3001\u672c\u7814\u7a76\u6210\u679c\u306b\u3088\u3063\u3066\u3001\u65b0\u305f\u306a\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u9032\u3080\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u30012023\u5e7410\u670813\u65e5\uff08\u91d1\uff09\u516c\u958b\u306eProceedings of the National Academy of Sciences\uff08PNAS\uff09\u8a8c\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u8ad6\u6587\u540d\uff1a2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses\uff082-\u30c1\u30aa\u30a6\u30ea\u30b8\u30f3\u306f\u30d7\u30e9\u30b9\u9396RNA\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u5e83\u57df\u7684\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3059\u6838\u9178\u30a2\u30ca\u30ed\u30b0\u3067\u3042\u308b\uff09
\nURL\uff1ahttps:\/\/doi.org\/10.1073\/pnas.2304139120<\/a><\/p>\n

\u8a73\u7d30\u306f\u3053\u3061\u3089<\/a><\/p>\n

<\/a>
\ns2U\u306f\u69d8\u3005\u306a\u30d7\u30e9\u30b9\u9396RNA\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30dd\u30a4\u30f3\u30c8 \u25cf\u5317\u5927\u5275\u85ac\u79d1\u5b66\u7814\u7a76\u6559\u80b2\u30bb\u30f3\u30bf\u30fc\u306e\u6838\u9178\u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u7528\u3044\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u5b9f\u65bd\u3002 \u25cf\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u3084\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3092\u542b\u3080\u8907\u6570\u306e\u30a6\u30a4\u30eb\u30b9\u7a2e\u306b\u5bfe\u3057\u3066\u5f37\u529b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3059s2U\u3092\u540c\u5b9a\u3002 \u25cf\u30c7\u30f3\u30b0\u71b1\u7b49\u306e\u6cbb […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-6779","post","type-post","status-publish","format-standard","hentry","category-sci"],"_links":{"self":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/comments?post=6779"}],"version-history":[{"count":1,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6779\/revisions"}],"predecessor-version":[{"id":6781,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/posts\/6779\/revisions\/6781"}],"wp:attachment":[{"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/media?parent=6779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/categories?post=6779"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lfsci.hokudai.ac.jp\/info\/wp-json\/wp\/v2\/tags?post=6779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}