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\u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u5148\u7aef\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u306e\u5317\u6751 \u6717\u8b1b\u5e2b\u3001\u540c\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u9662\u535a\u58eb\u5f8c\u671f\u8ab2\u7a0b 3 \u5e74\u306e\u85e4\u672c \u611b\u3001\u7c73\u56fd\u30ce\u30fc\u30b9\u30a6\u30a7\u30b9\u30bf\u30f3\u5927Richard Morimoto\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u3084\u524d\u982d\u5074\u982d\u578b\u8a8d\u77e5\u75c7\uff08FTD\uff09\u306e\u539f\u56e0\u3068\u306a\u308b TDP-43 \u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u306e\u7d30\u80de\u5185\u51dd\u96c6\u4f53\u5f62\u6210\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u30e2\u30c7\u30eb\u751f\u7269\u3067\u3042\u308b\u7dda\u866b\u3092\u7528\u3044\u3066\u51dd\u96c6\u4f53\u306b\u3088\u308b\u6bd2\u6027\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

TDP-43\u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u306e\u51dd\u96c6\u30e2\u30c7\u30eb(\u5de6)\u3068\u305d\u308c\u3092\u767a\u73fe\u3059\u308b\u7dda\u866b\u306e\u9855\u5fae\u93e1\u5199\u771f(\u53f3)<\/p>\n\n\n\n

\u672c\u6210\u679c\u3067\u306f\u3001TDP-43 \u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u304c\u51dd\u96c6\u3059\u308b\u6642\u3001\u3069\u306e\u9818\u57df\u304c\u3069\u3046\u3044\u3046\u63a8\u79fb\u3067\u51dd\u96c6\u3057\u3066\u3044\u304f\u306e\u304b\u3092\u3001\u30c9\u30e1\u30a4\u30f3\u6b20\u640d\u5909\u7570\u4f53\u3084\u30c9\u30e1\u30a4\u30f3\u4ea4\u63db\u5909\u7570\u4f53\u306a\u3069\u3092\u4f7f\u3063\u3066\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001TDP-43 \u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u306e N \u672b\u7aef\u30c9\u30e1\u30a4\u30f3\u304c\u6700\u521d\u306b\u69cb\u9020\u5909\u5316\u3057\u305f\u5f8c\u3001\u5206\u5b50\u9593\u306e\u4f1a\u5408\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u305d\u308c\u306b\u3088\u308a\u3001C \u672b\u7aef\u5074\u306e\u5143\u6765\u69cb\u9020\u3092\u53d6\u3089\u306a\u3044\u5929\u7136\u5909\u6027\u9818\u57df\u304c\u69cb\u9020\u5909\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u307e\u3060\u69cb\u9020\u5909\u5316\u3057\u3066\u3044\u306a\u3044TDP-43\u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u3084\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5dfb\u304d\u8fbc\u3093\u3067\u30a2\u30df\u30ed\u30a4\u30c9\u3092\u542b\u3080\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u5149\u306b\u3088\u308a\u6642\u7a7a\u9593\u3092\u5236\u5fa1\u3057\u3064\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4f1a\u5408\u3092\u8a98\u5c0e\u3067\u304d\u308b\u30bf\u30b0\u3092\u7528\u3044\u305f\u89e3\u6790\u306b\u3088\u308a\u3001TDP- 43\u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u306e\u5929\u7136\u5909\u6027\u9818\u57df\u306e N \u672b\u7aef\u5074\u306f\u8fd1\u63a5\u3057\u3084\u3059\u3044\u306e\u306b\u5bfe\u3057\u3001C \u672b\u7aef\u5074\u306f\u8fd1\u63a5\u3057\u306b\u304f\u3044\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u6709\u540d\u306a\u30e2\u30c7\u30eb\u751f\u7269\u3067\u3042\u308b\u7dda\u866b\u306bTDP-43\u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u3092\u767a\u73fe\u3055\u305b\u308b\u3068\u3001\u7dda\u866b\u5185\u3067\u3082\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3057\u307e\u3059\u304c\u3001\u6d41\u52d5\u6027\u306e\u4f4e\u3044\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u7dda\u866b\u3067\u306f\u904b\u52d5\u6027\u306e\u4f4e\u4e0b\u304c\u8d77\u3053\u308a\u3001\u77ed\u5bff\u547d\u3068\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u672c\u7814\u7a76\u3067\u78ba\u7acb\u3057\u305f\u624b\u6cd5\u304c\u5229\u7528\u3057\u3066TDP- 43\u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u306e\u51dd\u96c6\u5f62\u6210\u3092\u6291\u3048\u308b\u85ac\u5264\u8a55\u4fa1\u3092\u884c\u3046\u3053\u3068\u3067\u3001ALS\u3084FTD\u306e\u6cbb\u7642\u307e\u305f\u306f\u4e88\u9632\u6226\u7565\u306b\u671f\u5f85\u304c\u6301\u305f\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u306a\u304a\u3001\u672c\u7814\u7a76\u6210\u679c\u306f\u30012024 \u5e74 6 \u6708 20 \u65e5(\u6728)\u516c\u958b\u306e Communications Biology \u8a8c\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u8a73\u7d30\u306f\u4ee5\u4e0b\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

\u5317\u5927\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff1aALS\/FTD\u306e\u539f\u56e0\u3068\u306a\u308b\u51dd\u96c6\u4f53\u5f62\u6210\u6a5f\u69cb\u3092\u89e3\u660e\uff5e\u795e\u7d4c\u7d30\u80de\u306e\u6bd2\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6\u3092\u6291\u5236\u3059\u308b\u85ac\u5264\u306a\u3069\u306e\u7814\u7a76\u767a\u5c55\u306b\u671f\u5f85\uff5e<\/a><\/p>\n\n\n\n

\u8ad6\u6587\u540d Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity (TDP-43 \u30ab\u30eb\u30dc\u30ad\u30b7\u672b\u7aef\u65ad\u7247\u3068\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30d8\u30c6\u30ed\u30aa \u30ea\u30b4\u30de\u30fc\u5f62\u6210\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u6bd2\u6027\u306b\u5bc4\u4e0e\u3059\u308b)<\/p>\n\n\n\n

\u8457\u8005\u540d \u5317\u6751 \u6717 1*\u3001\u85e4\u672c \u611b 2*\u3001\u5ddd\u5cf6\u601c\u7dad 2(\u7814\u7a76\u5f53\u6642)\u3001Yidan Lyu2(\u7814\u7a76\u5f53\u6642)\u3001\u4f50\u3005\u6728\u864e\u5fb9 2\u3001\u6ff1\u7530\u60a0\u592a 2\u3001 \u68ee\u8c37\u9999\u5357 2(\u7814\u7a76\u5f53\u6642)\u3001\u5009\u7530\u6b69\u5b9f 3(\u7814\u7a76\u5f53\u6642)\u3001\u9ad8\u6a4b\u4e00\u5e06 3(\u7814\u7a76\u5f53\u6642)\u3001Rene\u00e9 Brielmann4\u3001Laura Bott4\u3001 Richard Morimoto4\u3001\u91d1\u57ce\u653f\u5b5d 1(1 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66\u9662\u5148\u7aef\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u30012 \u5317\u6d77\u9053\u5927\u5b66\u5927\u5b66 \u9662\u751f\u547d\u79d1\u5b66\u9662\u30013 \u5317\u6d77\u9053\u5927\u5b66\u7406\u5b66\u90e8\u30014 \u7c73\u56fd\u30ce\u30fc\u30b9\u30a6\u30a7\u30b9\u30bf\u30f3\u5927\u5b66\u3001*\u7b46\u982d\u5171\u8457\u8005)<\/p>\n\n\n\n

\u96d1\u8a8c\u540d Communications Biology (\u82f1\u56fd Nature Publishing Group \u767a\u884c\u306e\u751f\u7269\u30fb\u533b\u751f\u7269\u5b66\u8853\u8a8c) <\/p>\n\n\n\n

DOI 10.1038\/s42003-024-06410-3<\/a>
\u516c\u8868\u65e5 2024 \u5e74 6 \u6708 20 \u65e5(\u6728)(\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b)<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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